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Irbesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively binding into the AT1 angiotensin II receptor. There exists also an AT2 receptor in many tissues, but it is not involved with cardiovascular homeostasis.
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Blockade from the AT1 receptor gets rid of the detrimental feedback of angiotensin II on renin secretion, though the resulting amplified plasma renin exercise and circulating angiotensin II will not conquer the consequences of irbesartan on blood pressure level.
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The Bengals' roster has its' flaws. Some will say they must bolster the trenches. Some others will dismiss the thought of incorporating a 31-yr-old receiver that features a lengthy damage historical past.
Irbesartan's prevention of angiotensin II binding leads to vascular easy muscle rest and helps prevent the secretion of aldosterone, lowering hypertension.
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